Lab Funding

Targeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden Death
This project takes a systems approach to map ROS-sensitive pathways in HF progression.

18TPA34170575 | Preserving Cardiac Retinoic Acid Homeostasis as a Therapeutic Approach to Heart Failure
This goal of this grant is to characterize the factors that dictated levels of ATRA in Heart and how they are perturbed in the context of heart failure.

Division of Cardiology | Modulation of Cardiac all-trans Retinoic Acid Metabolism to Prevent Heart Failure
This award provides pilot funding for the development of CYP26 knockout mouse models to modulate levels of cardiac ATRA and determine its impact on TAC-induced hypertrophy.

Office of the Provost | The Role of Retinoic Acid Deficiency in the Pathogenesis of Heart Failure and Sudden Cardiac Death
This award provides pilot funding for the development of CYP26 knockout mouse models to modulate levels of cardiac ATRA and determine its impact on TAC-induced hypertrophy.

Completed or Declined

NIH/NHLBI | Role: Principal Investigator | A Systems Biology Approach to Cardiomyopathy in a D. melanogaster Model
The primary goal is to map the retrograde signaling from cardiomyopathy mutations using a quantitative proteomic approach.

AHA/National Center | Role: Principle Investigator | Characterizing MitoROMK, the K+ channel subunit of MitoKATP
This project aims to capitalize on the discovery of MitoROMK, to find and validate both binding partners and post-translational modifications of the pore-forming and regulatory subunits of MitoKATP.

AHA/Mid-Atlantic | Role: Principal Investigator | A Systems Biology Approach to Cardiomyopathy using D. melanogaster as a Model System
The primary goal is to map the retrograde signaling from cardiomyopathy mutations using a quantitative proteomic approach. It was declined to accept 12SDG12060056. The project was subsequently funded under R21HL108052.

AHA/Founders Affiliate | Role: Principal Investigator | Structural Investigation of Muscle Thin Filaments Using 3D Helical Image Reconstruction of Electron Micrographs

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