Publications
Fenwick AJ, Jani VP, Foster DB, Sharp TE, Goodchild TT, LaPenna K, Doiron JE, Lefer DJ, Hill JA, Kass DA, Cammarato A. Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics. J Am Heart Assoc. 2024 Jan 9:e032037. doi: 10.1161/JAHA.123.032037. Epub ahead of print. PMID: 38193306.
Salyer LG, Salhi HE, Brundage EA, Shettigar V, Sturgill SL, Zanella H, Templeton B, Abay E, Emmer KM, Lowe J, Rafael-Fortney JA, Parinandi N, Foster DB, McKinsey TA, Woulfe KC, Ziolo MT, Biesiadecki BJ. Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function. Circ Res. 2024 Jan 5;134(1):33-45. doi: 10.1161/CIRCRESAHA.123.323132. Epub 2023 Dec 14. PMID: 38095088.
Nidadavolu LS, Cosarderelioglu C, Merino Gomez A, Wu Y, Bopp T, Zhang C, Nguyen T, Marx-Rattner R, Yang H, Antonescu C, Florea L, Talbot CC, Smith B, Foster DB, Fairman JE, Yenokyan G, Chung T, Le A, Walston JD, Abadir PM. Interleukin-6 Drives Mitochondrial Dysregulation and Accelerates Physical Decline: Insights From an Inducible Humanized IL-6 Knock-In Mouse Model. J Gerontol A Biol Sci Med Sci. 2023 Oct 9;78(10):1740-1752. doi: 10.1093/gerona/glad147. PMID: 37310873; PMCID: PMC10562892.
Papanicolaou KN, Jung J, Ashok D, Zhang W, Modaressanavi A, Avila E, Foster DB, Zachara NE, O’Rourke B. Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy. J Biol Chem. 2023 Jan 12:102907. doi: 10.1016/j.jbc.2023.102907. Online ahead of print. PMID: 36642184
Xu M, Bermea KC, Ayati M, Kim HB, Yang X, Medina A, Fu Z, Heravi A, Zhang X, Na CH, Everett AD, Gabrielson K, Foster DB, Paolocci N, Murphy AM, Ramirez-Correa GA Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy. Commun Biol. 2022 Nov 15;5(1):1251. doi: 10.1038/s42003-022-04021-4.PMID: 36380187
Foster DB, Gu JM, Kim EH, Wolfson DW, O’Meally R, Cole RN, Cho HC. Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program. J Proteome Res. 2022 Oct 7;21(10):2277-2292. doi: 10.1021/acs.jproteome.2c00133. Epub 2022 Aug 25.PMID: 36006872
Nidadavolu LS, Stern D, Lin R, Wang Y, Li Y, Wu Y, Marin S, Antonio MJ, Yenokyan G, Boronina T, Cole R, Foster DB, Talbot C, Jedrych J, Smith B, Rini D, Le A, Cui H, Walston JD, . Valsartan nano-filaments alter mitochondrial energetics and promote faster healing in diabetic rat wounds. Abadir PM. Wound Repair Regen. 2021 Nov;29(6):927-937. doi: 10.1111/wrr.12974. Epub 2021 Oct 20.
Yang N, Parker LE, Yu J, Jones JW, Liu T, Papanicolaou KN, Talbot CC Jr, Margulies KB, O’Rourke B, Kane MA, Foster DB.. Cardiac retinoic acid levels decline in heart failure. JCI Insight. 2021 Apr 22;6(8):e137593. doi: 10.1172/jci.insight.137593.PMID: 33724958
Schmidt W, Madan A, Foster DB, and Cammarato A. Lysine acetylation of f-actin decreases tropomyosin-based inhibition of actomyosin activity. J Biol Chem. 2020. 295(46): p. 15527-15539. doi: 10.1074/jbc.RA120.015277 PMC7667958
Papanicolaou KN, Ashok D, Liu T, Bauer TM, Sun J, Li Z, da Costa E, D’Orleans CC, Nathan S, Lefer DJ, Murphy E, Paolocci N, Foster DB, and O’Rourke B. Global knockout of Romk potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of MitoKatp. J Mol Cell Cardiol. 2020. 139: p. 176-189. doi: 10.1016/j.yjmcc.2020.01.010 PMC7849919
Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, and Woulfe KC. Site-specific acetyl-mimetic modification of cardiac troponin i modulates myofilament relaxation and calcium sensitivity. J Mol Cell Cardiol. 2020. 139: p. 135-147. doi: 10.1016/j.yjmcc.2020.01.007 PMC7363438
Gu JM, Grijalva SI, Fernandez N, Kim E, Foster DB*, and Cho HC*. Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand. Exp Mol Med. 2019. 51(9): p. 1-12. doi: 10.1038/s12276-019-0303-6 PMC6802647
Dey S, DeMazumder D, Sidor A, Foster DB, O’Rourke B. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure. Circ Res. 2018 Jul 20;123(3):356-371. doi: 10.1161/CIRCRESAHA.118.312708. Epub 2018 Jun 13.PMID: 29898892
Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O’Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. JCI Insight. 2018; 3(6). PMID: 29563334 PMCID: PMC5926940
Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O’Rourke B, Abraham MR. Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status. JACC. Basic to translational science. 2017; 2(5):543-560. NIHMSID: NIHMS939086 PMID: 29520378 PMCID: PMC5839118
O’Rourke B, Liu T, and Foster DB Seeing the Forest for the Trees. Circ Res. 2016 Nov 11;119(11):1170-1172. PMID: 28051783
Foster DB, Liu T, Kammers K, O’Meally R, Yang N, Papanicolaou KN, Talbot CC Jr, Cole RN, O’Rourke B. Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death. J Proteome Res. 2016 Sep 2;15(9):3009-28. doi: 10.1021/acs.jproteome.6b00149. PMID: 27399916
Book
Manual of Cardiovascular Proteomics, Agnetti G, Lindsey ML, Foster DB Eds. Springer UK 2016. [Amazon]
Book Chapters
Kammers K, Foster DB, Ruczinski, I, Analysis of Proteomic Data in Manual of Cardiovascular Proteomics, Agnetti G, Lindsey ML, Foster DB Eds. Springer UK 2016 [Amazon]
Miller MR, Franklin S, Foster DB, Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics in Manual of Cardiovascular Proteomics, Agnetti G, Lindsey ML, Foster DB Eds. Springer UK 2016 [Amazon]
Murray CI, Chung HS, Papanicolaou K, Foster DB and Kohr MJ, Post-translational Modifications in the Cardiovascular Proteome in Manual of Cardiovascular Proteomics, Agnetti G, Lindsey ML, Foster DB Eds. Springer UK 2016. [Amazon]
Burks TN, Marx R, Powell L, Rucker J, Bedja D, Heacock E, Smith BJ, Foster DB, Kass D, O’Rourke B, Walston JD, Abadir PM. Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies. Oncotarget. 2015;6(14):11979-93. Epub 2015/05/29. PubMed PMID: 26019138.
Aon MA, Foster DB. Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies. Antioxid Redox Signal. 2015;22(17):1499-501. Epub 2015/04/07. doi: 10.1089/ars.2015.6349. PubMed PMID: 25843129.
Viswanathan MC, Blice-Baum AC, Schmidt W, Foster DB, Cammarato A. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Front Physiol. 2015;6:116. Epub 2015/05/15. doi: 10.3389/fphys.2015.00116. PubMed PMID: 25972811; PMCID: PMC4412121.
Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM. Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity. J Appl Physiol (1985). 2015;118(2):212-23. Epub 2014/10/18. doi: 10.1152/japplphysiol.00463.2014. PubMed PMID: 25324519; PMCID: PMC4297775.
Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J Mol Cell Cardiol. 2015;82:93-103. Epub 2015/03/17. doi: 10.1016/j.yjmcc.2015.03.006. PubMed PMID: 25771144; PMCID: PMC4405491.
Papanicolaou KN, O’Rourke B, Foster DB. Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria. Front Physiol. 2014;5:301. Epub 2014/09/18. doi: 10.3389/fphys.2014.00301. PubMed PMID: 25228883; PMCID: PMC4151196.
Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. Arch Biochem Biophys. 2014;554:11-21. Epub 2014/05/13. doi: 10.1016/j.abb.2014.04.017. PubMed PMID: 24814372; PMCID: PMC4121669.
Fitzgerald R, De Santiago B, Lee DY, Yang G, Kim JY, Foster DB, Chan-Li Y, Horton MR, Panettieri, Jr. RA, Wang R, and An SS. H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel. Biochem Biophys Res Commun. 2014 Mar 28;446(1):393-8. doi: 10.1016/j.bbrc.2014.02.129. Epub 2014 Mar 12
Wijnker PJM, Sequeira V, Foster DB, Li Y, dos Remedios CG, Murphy AM, Stienen GJM, and van der Velden J. Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. Am. J. Physiol. 2014 Feb 28. [Epub ahead of print]
Foster DB*, Liu T, Rucker J, O’Meally B2, Hitt L, Cole RN, and O’RourkeB. The Cardiac Acetyl-Lysine Proteome PLoS One. 2013 Jul 2;8(7):e67513. Print 2013.*corresponding author
Sequeira V, Wijnker PJM, Nijenkamp LAM, Najafi A, Witjas-Paalberends R, Regan JA, Boontje, N, ten Cate FJ, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, dos Remedios C, Stienen GJM, Michels M, van der Velden J. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins Circ Res. 2013 May 24;112(11):1491-505. doi: 10.1161/CIRCRESAHA.111.300436. Epub 2013 Mar 18
Editorial appears in Huke S and Knollman BJ, Is the Frank Starling Law Kaput? Circ. Res. May 24, 112(11):1409-1411 Faculty of 1000-Recommended: MacLeod, K. http://f1000.com/prime/718027223
Wijnker PJ, Foster DB, Tsao AL, Frazier AH, Dos Remedios C, Murphy AM, Stienen GJ, van der Velden J. Impact of site-specific phosphorylation of the protein kinase a sites ser23 and ser24 of cardiac troponin I in human cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013 Jan;304(2):H260-8, Epub 2012 Nov 9.
Gao WD*, Murray CI*, Ye T, Zhong X, DuMond JF, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N. Nitroxyl(HNO)-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res. 2012 Sep 28;111(8):1002-11.Editorial appears in: Ge et al. Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure: A Prequel to Novel Therapeutics?. Circ Res. 2012. Sept 28, 111: 964-956.
Foster DB*, Ho AS*, Rucker JR, Garlid A, Chen L, Sidor A, Garlid KD, O’Rourke B, Mitochondrial ROMK channel is a Molecular Component of MitoKATP Circ Res. 2012 Aug 3, 111(4):446-454. Epub 2012 July 17.Featured Article (Editor’s Pick): Editorial appears in: Rines et al.A New pROM King for the MitoKATP Dance: ROMK Takes the Lead. Circ. Res. 2012. Aug 3 111(4)Faculty of 1000-Recommended: 392-393 Schwartz Longacre L: 2012. F1000.com/717953626#eval793459236
Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Paolocci N, Su J, Lai S, Kirk J, Steenbergen C, Gerstenblith G, and Weiss RGCreatine Kinase Over-expression Improves Contractile Function in Murine Heart Failure: Causal Evidence that the Failing Heart is Energy Starved J Clin Invest. 2012 Jan 3;122(1):291-302.
O’Rourke B, Van Eyk, JE and Foster DB, Mitochondrial Protein Phosphorylation as a Regulatory Modality: Implications for Mitochondrial Dysfunction in Heart Failure Cong. Heart Fail. 2011 Nov;17(6):269-82.
Abadir P, Foster DB, Crow M, Cooke C, Jain A, Smith B, Fedarko N, O’Rourke B, Walston JThe Identification and Characterization of a Mitochondrial Angiotensin System Proc. Natl. Acad. Sci. U. S. A 2011 Sep 6;108(36):14849-54. Epub 2011 Aug 18.Cutting Edge Science Pick. Appears in: Inagami T. Mitochondrial Angiotensin receptors and aging Circ Res. 2011 Dec 9;109(12):1323-4.Faculty of 1000-Recommended: Brown N: 2011 f1000.com/13340037#eval14707164
Wang SB, Foster DB, Rucker J, O’Rourke B, Kass DA and Van Eyk JE. Redox Regulation of Mitochondrial ATP synthase: Implications for Cardiac Resynchronization Therapy Circ. Res. 2011 Sep 16;109(7):750-7. Epub 2011 Aug 4.Featured Article (Editor’s Pick). Editorial appears in: Zweier JL, Chen CA, Talukder MA. Cardiac resynchronization therapy and reverse molecular remodeling: importance of mitochondrial redox signaling. Circ. Res. 2011 Sep 16;109(7):716-9.
Cammarato A, Ahrens CH, Alayari NN, Qeli E, Rucker J, Zmasek C, Reedy MC, Gucek M, Cole RN, Van Eyk JE, Bodmer R, O’Rourke B, Bernstein SI, Foster DB A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster PLoS ONE. 2011 6(4): e18497. doi:10.1371/journal.pone.0018497. Top Advance:Barth AS, Ferguson JF and Musunuru K,Top Advances in Functional Genomics and Translational Biology for 2011 Circ. Cardiovasc. Genet. 2012, 5, 143-145.
Bonios M, Chang CY, Terrovitis J, Pinheiro A, Afzal JM, Barth A, Santaularia M, Foster DB, Engels J , Wahl R, Semenza G, Raman V, Abraham TP, Abraham MR. Constitutive HIF-1α expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart via paracrine mechanisms J. Cardiovasc. Transl. Res. 2011 Jun;4(3):363-72. Epub 2011 May 3.
Kooij V, Saes M, Jaquet K, Zaremba R, Foster DB, Murphy AM, dos Remedios C, van der Velden J, Stienen GJM Effect of Troponin I Ser23/24 Phosphorylation on Ca2+-Sensitivity in Human Myocardium Depends on Endogenous Phosphorylation Background J. Mol. Cell. Cardiol. 2010 May;48(5):954-63.
Galinska A, Hatch V, Craig R, Murphy AM, Van Eyk JE, Wang C-LA, Lehman W, Foster DB The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments Circ. Res. 2010 Mar 5;106(4):705-11. Epub 2009 Dec 24.
Hsu K, Chi N, Gucek M, Van Eyk JE, Cole RN, Lin M, Foster DB Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3 Blood. 2009 Aug 27;114(9):1919-28.
Foster DB, O’Rourke B, Van Eyk JE,What can mitochondrial proteomics tell us about cardioprotection afforded by preconditioning? Expert Rev. Proteomics. 2008 Oct;5(5):633-6.
Chang KC, Barth AS, Sasano T, Kizana E, Kashiwakura Y, Zhang Y, Foster DB, Marbán E. CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc. Natl. Acad. Sci. U. S. A. 2008 Mar 18;105(11):4477-82. Epub 2008 Mar 12.
Foster DB, Rucker JJ, Marbán E. Is Kir6.1 a subunit of mitoK(ATP)? Biochem. Biophys. Res. Commun. 2008, Feb 15, 366 (3): 649-646.
Narolska NA, Piroddi N, Belus A, Boontje NM, Scellini B, Deppermann S, Zaremba R, Musters RJ, Dos Remedios C, Jaquet K, Foster DB, Murphy AM, van Eyk JE, Tesi C, Poggesi C, van der Velden J, Stienen GJ. Impaired Diastolic Function After Exchange of Endogenous Troponin I with C-Terminal Truncated Troponin I in Human Cardiac Muscle. Circ. Res. 2006 Oct 27;99(9):1012-20.
Foster DB, Huang R, Hatch V, Craig R, Graceffa P, Lehman W, Wang CL. Modes of Caldesmon Binding to Actin: Sites of Caldesmon Contact and Modulation of Interactions by Phosphorylation. J. Biol. Chem. 2004 Dec 17; 279(51):53387-94.
Foster DB, Noguchi T, VanBuren P, Murphy AM, Van Eyk JE. C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning. Circ. Res. 2003 Nov 14;93(10):917-24.
Buscemi N, Foster DB, Neverova I, Van Eyk JE. p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I. Circ. Res. 2002 Sep 20;91(6):509-16.
Rembold CM, Foster DB, Strauss JD, Wingard CJ, Eyk JE. cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery. J. Physiol. 2000 May 1;524 Pt 3:865-78.
Foster DB, Shen LH, Kelly J, Thibault P, Van Eyk JE, Mak AS. Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction. J. Biol. Chem. 2000 Jan 21;275(3):1959-65.
Foster DB, Van Eyk JE. In search of the proteins that cause myocardial stunning. Circ. Res. 1999 Sep 3;85(5):470-2.
Van Eyk JE, Arrell DK, Foster DB, Strauss JD, Heinonen TY, Furmaniak-Kazmierczak E, Cote GP, Mak AS. Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J. Biol. Chem. 1998 Sep 4;273(36):23433-9.
Tsuruda TS, Watson MH, Foster DB, Lin JJ, Mak AS. Alignment of caldesmon on the actin-tropomyosin filaments. Biochem. J. 1995 Aug 1;309 (Pt 3):951-7.
