Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity

Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM. Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity. J Appl Physiol (1985). 2015;118(2):212-23. Epub 2014/10/18. doi: 10.1152/japplphysiol.00463.2014. PubMed PMID: 25324519; PMCID: PMC4297775.