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Welcome to the Laboratory of Cardiovascular Biochemistry

The Foster Lab uses a systems biology approach that encompasses proteomics, metabolomics, network modeling, as well as cellular and molecular assessments of cardiac function in heart failure and cardiac ischemic preconditioning. Protein networks are perturbed in heart disease in a manner that correlates only weakly with changes in mRNA transcripts. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism. Understanding the status of protein networks in the diseased state is, therefore, key to discovering new therapies.