The Role of Retinoid Metabolism in Diastolic Dysfunction and Heart Failure Funded by NIH

With the award of an R01 grant from the National Institutes of Health we are excited to begin a deep dive into understanding precisely how Vitamin A (retinol) is converted to all-trans retinoic acid (ATRA) in the adult mammalian heart and how retinoid metabolism becomes discombobulated in the setting of heart failure (see Research tab). These studies extend our longstanding collaboration with Dr. Maureen Kane (co-PI), of the University of Maryland School of Pharmacy.