Kyriakos’ O-GlcNac Work Published in JBC

Congrats to Kyriakos, whose study on the impact of O-GlcNacylation on the MAP kinases, p38 and Erk1/2 in cardiac myocytes was accepted for publication in the Journal of Biological Chemistry. This work was carried out in collaboration with Dr. Brian O’Rourke (Division of Cardiology) and Dr. Natasha Zachara (Dept of Biological Chemistry). Kyriakos’ studies were aided by our talented undergraduate students Jessica, Cecelia, Amir and Eddie.

Brian Speaks at the 8th International Caparica Conference on Analytical Proteomics

It was tough work, but someone had to do it. Brian was invited to present at the 8th International Caparica Conference on Analytical Proteomics in Caparica, Portugal (across the bay from Lisbon), July 18-21, 2022. Specifically, he talked about how the lab has used integrated proteomics (whole proteome and targeted MS quantification) and metabolomics to reveal a role for cardiac ATRA insufficiency in the pathogenesis of HF in both preclinical models and patients. The conference, organized by the indefatigable Jose Luis Capelo (NOVA University of Lisboa), featured an excellent keynote presentation from Christopher Overall (University of British Columbia) and American Journal of Physiology editor, Dr. Merry Lindsey (Meharry College). The program was strong and the venue afforded a beautiful vista of the Atlantic Ocean, two reasons Brian will definitely put the meeting on his calendar for 2024.

Brian Speaks at the 6th International Conference of Retinoids

It was a pleasure to present face-to-face at the 6th International Conference of Retinoids held June 5-10, at Ohio University in Athens, Ohio. The info-packed conference was chaired by Dr. Maureen Kane (U Maryland) and Alex Moise (Northern Ontario School of Medicine). We presented our latest work on the role of cardiac ATRA insufficiency in heart failure. Indeed, Hopkins was well represented, with Laszlo Nagy, Ph.D. who spoke on the role of RXRs in the epigenetic control of macrophage polarization and Keith West, DrPH, who gave a keynote address chronicling his work on the impact of Vitamin A supplementation in Asia…which was interrupted halfway through by an emergency tornado warning! Memorable on many levels.

Kyriakos earns CDA from the AHA

Congrats to Kyriakos for earning a career development award from the American Heart Association to study the role of O-GlcNacylation in the context of cardioprotection. Kyriakos is a highly talented researcher with a broad skill set in molecular cardiology. He will be in the market for an Assistant Professor position soon. Interested parties should contact kyriakos@jhu.edu.

Award from the Saving Tiny Hearts Society.

We are honored to have been awarded a 1-year grant from the Saving Tiny Hearts Society to initiate studies of the enzymes that underlie the metabolism in the human heart. The premise of the work is that notwithstanding advances in pediatric cardiac surgery, children born with CHD remain at risk of developing HF throughout their development to adulthood and beyond. We submit that proper retinoid metabolism and signaling is key to both human heart development and post-natal heart health, yet the enzymes responsible for the metabolism of retinol to retinoic acid in the human heart are largely unknown. This represents a fundamental knowledge gap in cardiac biology. We believe that identifying these enzymes represents a crucial first step toward the design of therapies to preserve cardiac ATRA homeostasis.