Kyriakos earns CDA from the AHA

Congrats to Kyriakos for earning a career development award from the American Heart Association to study the role of O-GlcNacylation in the context of cardioprotection. Kyriakos is a highly talented researcher with a broad skill set in molecular cardiology. He will be in the market for an Assistant Professor position soon. Interested parties should contact kyriakos@jhu.edu.

Award from the Saving Tiny Hearts Society.

We are honored to have been awarded a 1-year grant from the Saving Tiny Hearts Society to initiate studies of the enzymes that underlie the metabolism in the human heart. The premise of the work is that notwithstanding advances in pediatric cardiac surgery, children born with CHD remain at risk of developing HF throughout their development to adulthood and beyond. We submit that proper retinoid metabolism and signaling is key to both human heart development and post-natal heart health, yet the enzymes responsible for the metabolism of retinol to retinoic acid in the human heart are largely unknown. This represents a fundamental knowledge gap in cardiac biology. We believe that identifying these enzymes represents a crucial first step toward the design of therapies to preserve cardiac ATRA homeostasis.

JCI Insight Publishes our work on Cardiac Retinoic Acid Insufficiency in Heart Failure

The labors of the past few years came to fruition with the publication of Cardiac retinoic acid levels decline in heart failure in JCI Insight.Brian would like to extend tremendous thanks to all of the co-authors, but particularly our tireless visiting postdoc, Ni Yang (1st author), our super-talented undergraduate trainee, Lauren Parker, and our team of collaborators at the University of Maryland School of Pharmacy led by Dr. Maureen Kane. The project showcases the power of systems biology in action, with molecular and physiological experiments informed by multi-omic analysis and network inference.

Brian Speaks and Lauren Presents at BCVS 2018

Brian and Lauren hit the Basic Cardiovascular Sciences 2018 Scientific Sessions in San Antonio, July 31-Aug2, last week. Brian presented his invited seminar entitled Altered Retinostasis in Heart Failure in the Tuesday session on Transcriptional Regulation and Epigenetics. Stunning talks by all the speakers, including Enzo Porello from Murdoch Children’s Research Institute, Tom Vondriska from UCLA and Sam Bhattacharyya from UTSW.

Lauren presented her first poster at a national meeting entitled Characterization of the Mechanisms of Retinoic Acid-Mediated Suppression of Cardiac Hypertrophy, in the Wednesday afternoon poster session. She nailed it! Lots of traffic, interest and feedback.

Brian and Lauren would like to thank the organizers of the BCVS 2018 meeting for the opportunity to present their data.

American Heart Association logo

Foster Lab Awarded Grant from the American Heart Association

A few weeks ago we were thrilled to learn that the AHA has chosen to fund our work on altered retinoic acid homeostasis in heart failure progression with a Transformational Project Award. I wish to extend my thanks to the AHA, past and present members of the research team (Ni, Lauren & Kyriakos), as well as colleagues for their critical advice and support (you know who you are).