Publication of the Cardiac Acetyl-Lysine Proteome

Journal plos 1 imageOur most recent paper detailing the sites of lysine acetylation in the heart is now published in the online journal, PLOS One, and is also accessible through PubMed. One of the take home messages of the paper is that lysine acetylation in the heart goes beyond the well documented locations in the mitochondria and nucleus, and extends to  calcium-handling proteins of the sarcoplasmic reticulum and the sarcomere. We present novel acetylation sites and outline testable hypotheses by which lysine acetylation might modulate function of key proteins involved in excitation-contraction coupling.