Our most recent paper detailing the sites of lysine acetylation in the heart is now published in the online journal, PLOS One, and is also accessible through PubMed. One of the take home messages of the paper is that lysine acetylation in the heart goes beyond the well documented locations in the mitochondria and nucleus, and extends to calcium-handling proteins of the sarcoplasmic reticulum and the sarcomere. We present novel acetylation sites and outline testable hypotheses by which lysine acetylation might modulate function of key proteins involved in excitation-contraction coupling.
D. Brian Foster Ph.D.
Assistant Professor of Medicine
Division of Cardiology
Director, Laboratory of Cardiovascular Biochemistry
The Johns Hopkins University School of Medicine
Ross Research Building, Room 847
720 Rutland Avenue
Baltimore, MD 21205
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