Congrats to Kyriakos, whose study on the impact of O-GlcNacylation on the MAP kinases, p38 and Erk1/2 in cardiac myocytes was accepted for publication in the Journal of Biological Chemistry. This work was carried out in collaboration with Dr. Brian O’Rourke (Division of Cardiology) and Dr. Natasha Zachara (Dept of Biological Chemistry). Kyriakos’ studies were […]
It was tough work, but someone had to do it. Brian was invited to present at the 8th International Caparica Conference on Analytical Proteomics in Caparica, Portugal (across the bay from Lisbon), July 18-21, 2022. Specifically, he talked about how the lab has used integrated proteomics (whole proteome and targeted MS quantification) and metabolomics to […]
It was a pleasure to present face-to-face at the 6th International Conference of Retinoids held June 5-10, at Ohio University in Athens, Ohio. The info-packed conference was chaired by Dr. Maureen Kane (U Maryland) and Alex Moise (Northern Ontario School of Medicine). We presented our latest work on the role of cardiac ATRA insufficiency in […]
Congrats to Kyriakos for earning a career development award from the American Heart Association to study the role of O-GlcNacylation in the context of cardioprotection. Kyriakos is a highly talented researcher with a broad skill set in molecular cardiology. He will be in the market for an Assistant Professor position soon. Interested parties should contact […]
We are honored to have been awarded a 1-year grant from the Saving Tiny Hearts Society to initiate studies of the enzymes that underlie the metabolism in the human heart. The premise of the work is that notwithstanding advances in pediatric cardiac surgery, children born with CHD remain at risk of developing HF throughout their […]
The labors of the past few years came to fruition with the publication of Cardiac retinoic acid levels decline in heart failure in JCI Insight.Brian would like to extend tremendous thanks to all of the co-authors, but particularly our tireless visiting postdoc, Ni Yang (1st author), our super-talented undergraduate trainee, Lauren Parker, and our team […]
Brian and Lauren hit the Basic Cardiovascular Sciences 2018 Scientific Sessions in San Antonio, July 31-Aug2, last week. Brian presented his invited seminar entitled Altered Retinostasis in Heart Failure in the Tuesday session on Transcriptional Regulation and Epigenetics. Stunning talks by all the speakers, including Enzo Porello from Murdoch Children’s Research Institute, Tom Vondriska from […]
A few weeks ago we were thrilled to learn that the AHA has chosen to fund our work on altered retinoic acid homeostasis in heart failure progression with a Transformational Project Award. I wish to extend my thanks to the AHA, past and present members of the research team (Ni, Lauren & Kyriakos), as well […]
Dey S, DeMazumder D, Sidor A, Foster DB, O’Rourke B. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure. Circ Res. 2018 Jul 20;123(3):356-371. doi: 10.1161/CIRCRESAHA.118.312708. Epub 2018 Jun 13.PMID: 29898892
Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O’Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. JCI Insight. 2018; 3(6). PMID: 29563334 PMCID: PMC5926940
