Our review of Retinoic acid Signaling and Metabolism in Heart Failure is out in AJP. This behemoth took a while but was worth it. I (Brian) confess this comprehensive review was motivated by a few years of frustration with grant peer review comments about retinoid biology in of the heart that I’m sure were well-intended […]
We are thrilled to announce that our collaboration with our colleague, developmental cardiobiologist, Dr. Chulan Kwon, has been selected for funding from the U.S. Department of Defense. The project explores understudied sequelae of Down Syndrome gene dosage leading to septal defects that cannot be inferred from genomic or transcriptomic data alone. We use the tools […]
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With the award of an R01 grant from the National Institutes of Health we are excited to begin a deep dive into understanding precisely how Vitamin A (retinol) is converted to all-trans retinoic acid (ATRA) in the adult mammalian heart and how retinoid metabolism becomes discombobulated in the setting of heart failure (see Research tab). […]
Congrats to Kyriakos, whose study on the impact of O-GlcNacylation on the MAP kinases, p38 and Erk1/2 in cardiac myocytes was accepted for publication in the Journal of Biological Chemistry. This work was carried out in collaboration with Dr. Brian O’Rourke (Division of Cardiology) and Dr. Natasha Zachara (Dept of Biological Chemistry). Kyriakos’ studies were […]
It was tough work, but someone had to do it. Brian was invited to present at the 8th International Caparica Conference on Analytical Proteomics in Caparica, Portugal (across the bay from Lisbon), July 18-21, 2022. Specifically, he talked about how the lab has used integrated proteomics (whole proteome and targeted MS quantification) and metabolomics to […]
It was a pleasure to present face-to-face at the 6th International Conference of Retinoids held June 5-10, at Ohio University in Athens, Ohio. The info-packed conference was chaired by Dr. Maureen Kane (U Maryland) and Alex Moise (Northern Ontario School of Medicine). We presented our latest work on the role of cardiac ATRA insufficiency in […]
Congrats to Kyriakos for earning a career development award from the American Heart Association to study the role of O-GlcNacylation in the context of cardioprotection. Kyriakos is a highly talented researcher with a broad skill set in molecular cardiology. He will be in the market for an Assistant Professor position soon. Interested parties should contact […]
We are honored to have been awarded a 1-year grant from the Saving Tiny Hearts Society to initiate studies of the enzymes that underlie the metabolism in the human heart. The premise of the work is that notwithstanding advances in pediatric cardiac surgery, children born with CHD remain at risk of developing HF throughout their […]
The labors of the past few years came to fruition with the publication of Cardiac retinoic acid levels decline in heart failure in JCI Insight.Brian would like to extend tremendous thanks to all of the co-authors, but particularly our tireless visiting postdoc, Ni Yang (1st author), our super-talented undergraduate trainee, Lauren Parker, and our team […]
