Entries by admin

Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity

Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM. Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity. J Appl Physiol (1985). 2015;118(2):212-23. Epub […]

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J Mol Cell Cardiol. 2015;82:93-103. Epub 2015/03/17. doi: 10.1016/j.yjmcc.2015.03.006. PubMed PMID: 25771144; […]

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. Arch Biochem Biophys. 2014;554:11-21. Epub 2014/05/13. doi: 10.1016/j.abb.2014.04.017. PubMed PMID: 24814372; PMCID: PMC4121669.

­The Cardiac Acetyl-Lysine Proteome

Foster DB*, Liu T, Rucker J, O’Meally B2, Hitt L, Cole RN, and O’RourkeB. ­The Cardiac Acetyl-Lysine Proteome PLoS One.  2013 Jul 2;8(7):e67513. Print 2013.*corresponding author

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins

Sequeira V, Wijnker PJM, Nijenkamp LAM,  Najafi A, Witjas-Paalberends R, Regan JA, Boontje, N, ten Cate FJ, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, dos Remedios C, Stienen GJM, Michels M, van der Velden J. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin […]