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Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins

Sequeira V, Wijnker PJM, Nijenkamp LAM,  Najafi A, Witjas-Paalberends R, Regan JA, Boontje, N, ten Cate FJ, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, dos Remedios C, Stienen GJM, Michels M, van der Velden J. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin […]

Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure: A Prequel to Novel Therapeutics?.

Gao WD*, Murray CI*, Ye T, Zhong X, DuMond JF, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N. Nitroxyl(HNO)-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res. 2012 Sep 28;111(8):1002-11.Editorial appears in: Ge et al. Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure: A Prequel to […]

A New pROM King for the MitoKATP Dance: ROMK Takes the Lead.

Foster DB*, Ho AS*, Rucker JR, Garlid A, Chen L, Sidor A, Garlid KD, O’Rourke B, Mitochondrial ROMK channel is a Molecular Component of MitoKATP Circ Res. 2012 Aug 3, 111(4):446-454. Epub 2012 July 17.Featured Article (Editor’s Pick): Editorial appears in: Rines et al.A New pROM King for the MitoKATP Dance: ROMK Takes the Lead. […]

Creatine Kinase Over-expression Improves Contractile Function in Murine Heart Failure: Causal Evidence that the Failing Heart is Energy Starved

Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Paolocci N,  Su J, Lai S, Kirk J,  Steenbergen C,  Gerstenblith G, and Weiss RGCreatine Kinase Over-expression Improves Contractile Function in Murine Heart Failure: Causal Evidence that the Failing Heart is Energy Starved J Clin Invest. 2012 Jan 3;122(1):291-302.

Angiotensin receptors and aging

Abadir P, Foster DB, Crow M, Cooke C, Jain A, Smith B, Fedarko N, O’Rourke B, Walston JThe Identification and Characterization of a Mitochondrial Angiotensin System Proc. Natl. Acad. Sci. U. S. A 2011 Sep 6;108(36):14849-54. Epub 2011 Aug 18.Cutting Edge Science Pick. Appears in: Inagami T. Mitochondrial Angiotensin receptors and aging Circ Res. 2011 […]

Cardiac resynchronization therapy and reverse molecular remodeling: importance of mitochondrial redox signaling

Wang SB, Foster DB, Rucker J, O’Rourke B, Kass DA and Van Eyk JE. Redox Regulation of Mitochondrial ATP synthase: Implications for Cardiac Resynchronization Therapy Circ. Res. 2011 Sep 16;109(7):750-7. Epub 2011 Aug 4.Featured Article (Editor’s Pick). Editorial appears in: Zweier JL, Chen CA, Talukder MA. Cardiac resynchronization therapy and reverse molecular remodeling: importance of […]