Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.

Dey S, DeMazumder D, Sidor A, Foster DB, O’Rourke B. Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure. Circ Res. 2018 Jul 20;123(3):356-371. doi: 10.1161/CIRCRESAHA.118.312708. Epub 2018 Jun 13.PMID: 29898892

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models

Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O’Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. JCI Insight. 2018; 3(6). PMID: 29563334 PMCID: PMC5926940

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status.

Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O’Rourke B, Abraham MR. Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status. JACC. Basic to translational science. 2017; 2(5):543-560. NIHMSID: NIHMS939086 PMID: 29520378 PMCID: PMC5839118

Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death

Foster DB, Liu T, Kammers K, O’Meally R, Yang N, Papanicolaou KN, Talbot CC Jr, Cole RN, O’Rourke B. Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death. J Proteome Res. 2016 Sep 2;15(9):3009-28. doi: 10.1021/acs.jproteome.6b00149. PMID: 27399916

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Burks TN, Marx R, Powell L, Rucker J, Bedja D, Heacock E, Smith BJ, Foster DB, Kass D, O’Rourke B, Walston JD, Abadir PM. Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies. Oncotarget. 2015;6(14):11979-93. Epub 2015/05/29. PubMed PMID: 26019138.

Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies

Aon MA, Foster DB. Diabetic cardiomyopathy and the role of mitochondrial dysfunction: novel insights, mechanisms, and therapeutic strategies. Antioxid Redox Signal. 2015;22(17):1499-501. Epub 2015/04/07. doi: 10.1089/ars.2015.6349. PubMed PMID: 25843129.

Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance

Viswanathan MC, Blice-Baum AC, Schmidt W, Foster DB, Cammarato A. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Front Physiol. 2015;6:116. Epub 2015/05/15. doi: 10.3389/fphys.2015.00116. PubMed PMID: 25972811; PMCID: PMC4412121.

Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity

Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM. Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity. J Appl Physiol (1985). 2015;118(2):212-23. Epub 2014/10/18. doi: 10.1152/japplphysiol.00463.2014. PubMed PMID: 25324519; PMCID: PMC4297775.

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. J Mol Cell Cardiol. 2015;82:93-103. Epub 2015/03/17. doi: 10.1016/j.yjmcc.2015.03.006. PubMed PMID: 25771144; PMCID: PMC4405491.