Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria

Papanicolaou KN, O’Rourke B, Foster DB. Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria. Front Physiol. 2014;5:301. Epub 2014/09/18. doi: 10.3389/fphys.2014.00301. PubMed PMID: 25228883; PMCID: PMC4151196.

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes. Arch Biochem Biophys. 2014;554:11-21. Epub 2014/05/13. doi: 10.1016/j.abb.2014.04.017. PubMed PMID: 24814372; PMCID: PMC4121669.

H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel.

Fitzgerald R, De Santiago B, Lee DY, Yang G, Kim JY, Foster DB, Chan-Li Y, Horton MR, Panettieri, Jr. RA, Wang R, and An SS. H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel. Biochem Biophys Res Commun. 2014 Mar 28;446(1):393-8. doi: 10.1016/j.bbrc.2014.02.129. Epub 2014 Mar 12

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Wijnker PJM, Sequeira V, Foster DB, Li Y, dos Remedios CG, Murphy AM, Stienen GJM, and van der Velden J. Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation. Am. J. Physiol. 2014 Feb 28. [Epub ahead of print]

­The Cardiac Acetyl-Lysine Proteome

Foster DB*, Liu T, Rucker J, O’Meally B2, Hitt L, Cole RN, and O’RourkeB. ­The Cardiac Acetyl-Lysine Proteome PLoS One.  2013 Jul 2;8(7):e67513. Print 2013.*corresponding author

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins

Sequeira V, Wijnker PJM, Nijenkamp LAM,  Najafi A, Witjas-Paalberends R, Regan JA, Boontje, N, ten Cate FJ, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, dos Remedios C, Stienen GJM, Michels M, van der Velden J. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with sarcomere mutations in myosin and thin filament proteins Circ Res. 2013 May 24;112(11):1491-505. doi: 10.1161/CIRCRESAHA.111.300436. Epub 2013 Mar 18F1000Editorial appears in Huke S and Knollman BJ, Is the Frank Starling Law Kaput? Circ. Res. May 24, 112(11):1409-1411 Faculty of 1000-Recommended: MacLeod, K. http://f1000.com/prime/718027223

Impact of site-specific phosphorylation of the protein kinase a sites ser23 and ser24 of cardiac troponin I in human cardiomyocytes.

Wijnker PJ, Foster DB, Tsao AL, Frazier AH, Dos Remedios C, Murphy AM, Stienen GJ, van der Velden J. Impact of site-specific phosphorylation of the protein kinase a sites ser23 and ser24 of cardiac troponin I in human cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013 Jan;304(2):H260-8, Epub 2012 Nov 9.

Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure: A Prequel to Novel Therapeutics?.

Gao WD*, Murray CI*, Ye T, Zhong X, DuMond JF, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N. Nitroxyl(HNO)-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res. 2012 Sep 28;111(8):1002-11.Editorial appears in: Ge et al. Nitroxyl, Redox Switches, Cardiac Myofilaments, and Heart Failure: A Prequel to Novel Therapeutics?. Circ Res. 2012. Sept 28, 111: 964-956.

A New pROM King for the MitoKATP Dance: ROMK Takes the Lead.

badgef1000Foster DB*, Ho AS*, Rucker JR, Garlid A, Chen L, Sidor A, Garlid KD, O’Rourke B, Mitochondrial ROMK channel is a Molecular Component of MitoKATP Circ Res. 2012 Aug 3, 111(4):446-454. Epub 2012 July 17.Featured Article (Editor’s Pick): Editorial appears in: Rines et al.A New pROM King for the MitoKATP Dance: ROMK Takes the Lead. Circ. Res. 2012. Aug 3 111(4)Faculty of 1000-Recommended: 392-393 Schwartz Longacre L: 2012. F1000.com/717953626#eval793459236

Creatine Kinase Over-expression Improves Contractile Function in Murine Heart Failure: Causal Evidence that the Failing Heart is Energy Starved

Gupta A, Akki A, Wang Y, Leppo MK, Chacko VP, Foster DB, Paolocci N,  Su J, Lai S, Kirk J,  Steenbergen C,  Gerstenblith G, and Weiss RGCreatine Kinase Over-expression Improves Contractile Function in Murine Heart Failure: Causal Evidence that the Failing Heart is Energy Starved J Clin Invest. 2012 Jan 3;122(1):291-302.